ABSTRACT
Human synovial cells from cases of rheumatoid and osteoarthritis were cultured and at their 3-5 passages, were treated with gold thiomalate. At early-log phase gold thiomalate arrested the proliferation of cells. However, at confluent state shere was a slight proliferation of synovial cells. This was followed by an increase in prolyl hydroxylase, collagen and protein synthesis, indicating that gold salts directly stimulate the synovial cells.
Subject(s)
Arthritis, Rheumatoid/drug therapy , Cell Division/drug effects , Cells, Cultured , Collagen/biosynthesis , Gold Sodium Thiomalate/pharmacology , Humans , Procollagen-Proline Dioxygenase/metabolism , Synovial Membrane/cytologyABSTRACT
O emprego do aurotiomalato de sódio mostrou-se efetivo em 80% dos pacientes, com apreciável efeito córtico-economizador. Os paraefeitos ocorreram em percentagem insignificante. A terapia remissiva deve ser utilizada em estágios precoces da enfermidade, associada aos antiinflamatórios e medidas físico e psicoterápicas